In the following article ways to cure the Testosterone deficiency will be discussed with special reference to two drugs tamoxifen and Clomid, their mechanism of action, and how they should be consumed to raise testosterone levels. Firstly, we will discuss what is testosterone and the causes of its reduced levels.
Testosterone is the primary male sex hormone in the males for their sexual development and is also known as androgen. Sexual development can be divide into two types; primary sexual development and secondary sexual development the former refers to the maturation of testes (for sperm production) and prostate (a gland that produces semen) whereas secondary development refers to voice coarseness, hair growth on the whole body in the form of muscle mass and libido (sex drive). It is also present in females but in very less amounts in the ovaries and helps in the repair growth and overall maintenance of reproductive system, bone mass and behaviors along with other hormones for example estrogen. People with deficiency tend to use testosterone UK to replenish the deficiency, other off label drugs are also used which will be discussed further.
CAUSES OF LOW TESTOSTERONE COUNT:
There can be multiple factors and reasons attributing to low testosterone levels and are different in males and females, the term used for low testosterone count is hypogonadism and causes are as follows:
- Infection of the testes
- Trauma to the testes
- Over or under weight
- Alcohol abuse
- Medications for example opioids and steroids.
- Cirrhosis of liver
- HIV or AIDS
- Acute and chronic illnesses
- Malfunctioning of pituitary glands
- Syndromes for example Klinefelter syndrome
- Hormonal disturbance, in the case of high prolactin level.
- Un-controlled diabetes
- Radiation exposure
- Advanced age
In females the causes can be as follows:
- Adrenal gland insufficiency
- Surgical removal of ovaries known as oophorectomy
DRUGS TO RAISE TESTOSTERONE LEVELS:
To raise the levels of testosterone different drugs are there which are prescribed, some of the commonly used to cure the deficiency are as follows:
- Testosterone replacement therapy
In the following headings, tamoxifen and Clomid will be discuss in detail to raise testosterone levels.
Tamoxifen is sold in the market with the brand name of Nolvadex, it is a selective estrogen receptor modulator. It is metabolized in the liver by the body and shows the protein binding up to 99 percent to the albumin protein and has an elimination half-life of five to seven days.
Available in two forms in the market
- Solid form known as pill with the brand name of Nolvadex.
- Liquid preparation sold with the brand name of saltamox.
MECHANISM OF ACTION:
The mechanism of action through which raise in testosterone levels are observed will be discussed, it blocks the pathway through which estrogen is produced it stops the negative feedback mechanism of estrogen on the pituitary and hypothalamus gland thus decreased estrogen results in increased testosterone levels by increment in Luteinizing hormone and follicular stimulating hormone levels hence, testosterone biosynthesis occurs and it stimulates sperm production.
This drug is use to treat the following conditions:
- To prevent breast tumors in women.
- Treat breast cancers in women and men.
- Shrink the size of tumor before surgery.
- To restore bone density compromised after menopause.
- Useful in studying different types of cancers.
- Used in Albright syndrome.
- To raise testosterone levels.
Side effects observed after taking tamoxifen are:
- Pain in the pelvis area
- Shortness of breath
- Numbness in face, arm or legs
- Sudden severe headache
- Bone pain
- Hot flashes
- Mood swings and depression
- Loss of libido
- Thinning of hairs
HOW TO USE TAMOXIFEN:
Tamoxifen is used primarily in women to cure their breast cancer-related issues. However, in men, it is used off-label to treat fertility issues related to elevated estradiol levels. 20 milligrams per day is taken and the duration of intake depends on the severity of condition and usually ranges from 3 months to 9 months.
Clomid in men is the most widely used drug for treating fertility issues that is caused by disturbed hormonal balance. Its brand name is clomiphene citrate. FDA the food and drug association of united states has not approved it for treating male infertility still it is sold off label and males buy Clomid UK to treat their fertility-related concerns.
The medication is available in the market in the form of tablets of different potency. The dosage for men ranges from 12 milligrams per day to 400 milligrams in a day. Loading dose or the initial dose can be prescribed up to 50 milligrams a day depending upon the severity of the problem.
MECHANISM OF ACTION:
Clomiphene works through creating a perfect testosterone and estradiol ratio in men with hypogonadism by blocking the interaction of estrogen hormone with the pituitary gland, a pea sized gland present in the brain responsible for regulating the reproductive cycle through hormonal balance, as the pathway is blocked hence other hormones including testosterone, their surge in the blood stream increases thus improving the sperm production, sperm count and reduction in the number of abnormal sperms.
Individuals buy Clomid UK as an off-label drug to address their fertility concern typically when the fertility issue is due to low levels of testosterone in the blood.
The un-wanted or adverse effects are list below:
- Alterations in mood
- Gastro-intestinal disturbances
- Visual impairments
- Hot flushes
Men and women with testosterone deficiency treat in through different ways, Clomid and tamoxifen are used as an off-label option they also buy test UK. Clomid in low dose has proved very effective but risk benefit ratio should always be weighed and proper consultation should be ensured to reap maximum benefits and avoid adverse effects as much as possible.